Kenneth Kalunian, MD, professor of medicine and co-director of the Center for Innovative Therapy, UC San Diego School of Medicine, La Jolla, California, discusses the integration of patient-centered approaches to the management of rheumatoid arthritis. He discusses challenges with traditional biologic and DMAR therapies related to tolerability, response, and resistance. Dr Kalunian also focuses on the role of JAK inhibitors and how they may be leveraged for patient-centric management.